His first big success was to write and perform, with his vocal quartet The Keynotes, the theme to the successful comedy series Take It From Here in 1948.
Guest appearances by fellow Australian Dick Bentley led to the pairing of Bentley's writer Denis Norden with Edwards and Nichols' writer Frank Muir on Take It From Here (1948–1960), starring Edwards, Bentley and Nichols, who both sang and played comedy.