The southern end of the route is in Natchez at an intersection with Liberty Road, and the northern end is northeast of Fairview, Tennessee, in the suburban community of Pasquo, Tennessee, at an intersection with Tennessee 100.
After operating for over 40 years as a K-8 school, Ensworth added a high school in 2004, located on Tennessee State Route 100 adjacent to Edwin Warner Park and known as the Devon Farm Campus.
They are bounded on the northwest by Tennessee State Route 100, on the east and north by Chickering Road, and partially on the south by Old Hickory Blvd. and Vaughn Road.
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