In the Sherlock Holmes short story, The Adventure of the Speckled Band, while commenting on the apparent villain, Dr Grimesby Roylott, Holmes tells Dr Watson that when a doctor goes bad he is the first of criminals.
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Unlike most other adaptations of the Holmes stories, which retell only one of the original stories by Arthur Conan Doyle, this film incorporates elements from the novel The Sign of the Four, as well as the short stories "The Final Problem", "The Adventure of the Empty House", "The Adventure of the Devil's Foot" and "The Adventure of the Speckled Band".