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He has also appeared in several well-received films, such as Stonewall, The Business of Strangers, The Shape of Things, and the 2000 drama/miniseries The Beach Boys: An American Family portraying the character Brian Wilson.
He went on to direct and write the screenplay for The Business of Strangers in 2001, which earned him a Grand Jury Prize nomination at the Sundance Film Festival of that year and earned lead actress Stockard Channing an AFI nomination for Best Female Actress.
Weller has also played lead roles in many successful independent films, including Neil Labute's The Shape of Things (with Paul Rudd, Rachel Weisz and Gretchen Mol), James Tobak's When Will I Be Loved (opposite Neve Campbell) and The Business of Strangers (with Stockard Channing and Julia Stiles).