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Edward Leigh, 5th Baron Leigh (1742–1786) was descended from Thomas Leigh, Lord Mayor of London in 1558, and inherited the Leigh family seat at Stoneleigh Abbey, Stoneleigh, Warwickshire following the death of father Thomas Leigh, 4th Baron Leigh in 1749.
Leigh was the son of Sir John Leigh, 1st Baronet, of Stoneleigh, Warwickshire, and his first wife Ursula Hoddesdon, daughter of Sir Christopher Hoddesdon, of Leighton Buzzard, Bedfordshire.