Born in Paris, the son of Laetitia Bonaparte-Wyse, daughter of Lucien Bonaparte and estranged wife of the Irish politician Sir Thomas Wyse, Lucien Napoléon Bonaparte-Wyse's real father was a British army officer, Captain Studholm John Hodgson.
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He was the grandson of Sir Thomas Wyse, a Member of Parliament and educational reformer, and great-grandson of Lucien Bonaparte.
William Charles Bonaparte-Wyse was born in Waterford, the son of the politician and educational reformer Sir Thomas Wyse, and Laetitia, daughter of Lucien Bonaparte.