The phrase was first used to describe an inclination to become unfaithful after seven years of marriage in the play The Seven Year Itch (play) by George Axelrod, and gained popularity following the 1955 film adaptation starring Marilyn Monroe and Tom Ewell.
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The cast also included Leonard Frey as the villain Parker Tillman, Tom Ewell as the drunken town doctor Jerome Kullens, and Tracey Walter as Tillman's clueless, but kind-hearted henchman, Frog Rothchild, Jr.