Massachusetts | Massachusetts Institute of Technology | Cambridge, Massachusetts | Massachusetts House of Representatives | Massachusetts General Hospital | Lowell, Massachusetts | Worcester, Massachusetts | University of Massachusetts Amherst | Andover, Massachusetts | Springfield, Massachusetts | Salem, Massachusetts | Medford, Massachusetts | Brookline, Massachusetts | U.S. Route 66 | Newton, Massachusetts | U.S. Route 1 | Williamstown, Massachusetts | Somerville, Massachusetts | Lawrence, Massachusetts | U.S. Route 6 | U.S. Route 101 | Newburyport, Massachusetts | Middlesex County, Massachusetts | Lexington, Massachusetts | Waltham, Massachusetts | Route 66 | Governor of Massachusetts | U.S. Route 30 | Provincetown, Massachusetts | Pittsfield, Massachusetts |
In Danvers, the route has consecutive interchanges with U.S. Route 1 (along the Newburyport Turnpike) and I-95, just north of the former Danvers State Hospital site.
Route 99 begins at the intersection of New Rutherford Avenue and Chelsea Street, over the northbound tunnel of U.S. Route 1 created during the Big Dig.