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Liz Carmouche was originally scheduled to face former Strikeforce Women's Bantamweight Champion Miesha Tate at UFC on FOX 8, but Tate instead replaced the injured Cat Zingano on the The Ultimate Fighter.
On February 9, 2013, the UFC announced that Larkin would make his debut against Francis Carmont at UFC on Fox: Henderson vs. Melendez in San Jose, California.
Ovince returned to action less than a month after his win over Britt to fight UFC and Strikeforce veteran Benji Radach on the main card of Strikeforce: Henderson vs. Babalu II.
The Fighter Exchange Program is intended to be a tie-in to the Career Mode of the EA Sports MMA game, and features multimedia documentation of four young prospects (Bettega, Cummins, Martytniuok, Phillips) traveling, learning, and training with four established veterans (Jacare Souza, Jason Miller, Gegard Mousasi, Luke Rockhold).
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Herschel Walker pulled out of his fight with Scott Carson due to a cut under his left eye.
Johnny Bedford was expected to face Nick Denis at the event, but Bedford was forced out of the bout with an injury and replaced by Roland Delorme.
On July 30, 2012, UFC president Dana White confirmed that the winner of the main event will receive a Light Heavyweight title shot, regardless of how impressive either Ryan Bader or Lyoto Machida were in the co-main event of the evening.
Zuffa CEO Lorenzo Fertitta confirmed that the debut show would be a one hour special with only the main event airing live on television, but a full preliminary card taking place beforehand.