Much of the game takes place on the USS Voyager, shooting various alien intruders such as the Borg, Hirogen Hunters, Species 8472 as well as several other alien species from the Star Trek universe.
In the Star Trek: Voyager novel Unworthy, the chief engineer of the da Vinci, Nancy Conlon, has transferred to the same position aboard the USS Voyager.
Star Trek: Voyager | Voyager 1 | Voyager 2 | USS Monitor | Voyager | USS Constitution | USS ''Constitution'' | Voyager Golden Record | Voyager program | USS Defiant | USS ''Monitor'' | USS Enterprise (NCC-1701) | USS Cole bombing | USS New Ironsides | USS Merrimack | USS Enterprise (CV-6) | USS ''Enterprise'' | Rutan Voyager | USS ''Somers'' | USS Quincy (CA-71) | USS Quincy | USS Pueblo | USS ''Nautilus'' | USS ''Merrimac'' | USS ''Lexington'' | USS ''Kearsarge'' | USS Enterprise (NCC-1701-D) | USS Enterprise (NCC-1701-B) | USS Enterprise | USS ''Defiant'' |