A study at University Medical Center Groningen involved supervised bee sting therapy (using live bees) administered to 26 patients over a period of 24 weeks, compared to a 24-week period with no treatment.
A randomized, double-blind, placebo-controlled cross-over study by the University Medical Center Groningen reported that dishydrosis outbreaks on the hands increased significantly among those allergic to house dust mites, following inhalation of house dust mite allergen.
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The Groningen Protocol is a text created in September 2004 by Eduard Verhagen, the medical director of the department of pediatrics at the University Medical Center Groningen (UMCG) in Groningen, the Netherlands.