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Malesco is the most populous comune in Val Vigezzo and has a station on the Domodossola–Locarno railway which runs along the valley.
The Melezzo Orientale (known in the Swiss part of its course as the Melezza), a tributary of the Maggia which flows eastwards through the Val Vigezzo in Italy and the Centovalli in Switzerland
The Melezzo Occidentale, a tributary of the Toce which flows westwards through the Italian Val Vigezzo.
The river is formed by the confluence of various streams to the west of Druogno (which marks the watershed between the western and eastern sections of the Val Vigezzo), and runs westward through the narrow valley which connects the high plain of the central Val Vigezza to the Val d’Ossola.
To begin with the river runs south forming the deep valley of Arvogno (a locality within the commune of Toceno); near Santa Maria Maggiore (VB) the course turns east and takes it through the gentler slopes of the high plain which forms the central section of the Val Vigezzo; at Malesco it is joined by the Loana.