It deals with Doctor Doom's covert overthrow of the royal family of Wakanda and the following clash with various members of the superhuman community.
In the second film, Kleiser under orders of the Chitauri hierarchy, invades Wakanda to reclaim their Vibranium shipment shot down in the '40s. Kleiser was then buried in a field of the mineral by Captain America and the Black Panther, the latter whose father, King T'Chalka, was murdered by Kleiser. In the final conflict, Panther, and Cap sealed Kleiser in Wakanda's vibranium deposits.
Lady Octopus has been hired by Walter Declun (a former member of Damage Control) to assist Absorbing Man, Hydro-Man, Killer Shrike, a Mandroid, Porcupine II, and Rock to defend him from Black Panther and the Fantastic Four after they uncovered his plot to destabilize all of Wakanda on Doctor Doom's behalf.