From its western terminus, the route heads on a curvy northeasterly path roughly following the Yadkin River.
From this point in Yadkin County, the route travels in an easterly direction over Interstate 77, through Boonville and East Bend before crossing the Yadkin River into Forsyth County.
The school's first campus was located on the southern bank of the Yadkin River in Wilkesboro, the county seat.
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Between 1790-1800 a road was established through the area, connecting the Yadkin River Valley (near Wilkesboro) to Trade, Tennessee.
The Yadkin had already been developed in the prior decade by Alcoa to produce electricity for their smelting facility in Badin.
On February 7, 1781, General Cornwallis, in pursuit of American General Nathanael Greene, led his troops across the Yadkin River at the Shallow Ford.