In 1971, a New England Journal of Medicine editorial calling attention to previously published studies on the use of DES as a postcoital contraceptive at Yale University, and a large study published in JAMA on the use of DES as a postcoital contraceptive at the University of Michigan, led to off-label use of DES as a postcoital contraceptive becoming prevalent at many university health services.
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In the early 1970s, the Yuzpe regimen was developed by A. Albert Yuzpe in 1974;
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She launch successful legal efforts from the approval of emergency contraception for women by the FDA, to the application of international rape law to ensure the rights of women in the Iraq High Tribunal prosecutions of Saddam-era war crimes (see Trial of Saddam Hussein).