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The focus of his research has been investigating how local environmental factors (e.g. enemies, resources, disturbance regime and recruitment limitation) interact with post-invasion adaptation to determine the likelihood and severity of Chinese tallow tree (Sapium sebiferum) invasions into East Texas coastal prairie, mesic forests, and floodplain forests.
With regard to the cause of autism, Buie said, in an interview with PBS NewsHour, that "there are over 100 suspect genes that are associated with a higher frequency of autism. So there is clearly an underlying genetic predisposition to this condition in many children. But the possibility that there is some environmental factor or some extrinsic factor that affects those children, I think, still needs to sit on the table."