For example reconstructed human epidermis—which uses human skin donated from cosmetic surgery to replace the rabbit Draize skin test—is more relevant to human reactions.
The viviparous females drill tunnels in the epidermis where they give birth to six-legged larvae, which mutate through two eight-legged nymphal stages from the second of which the adults molt.
Once the fungus has entered the stratum corneum is continues to invade the epidermis, it then enters a hair follicle, penetrates the hair shaft and grows down the length of the hair.
Lymphocytes move to the epidermis where they reside as a memory T cells, they will thus be activated and will trigger inflammatory response.