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During the Manhattan Project, Dunning conducted pioneering work at Columbia University on gaseous diffusion to separate uranium isotopes; others working on the project included Booth, Henry A. Boorse, Willard F. Libby, Alfred O. C. Nier, and Francis G. Slack.
One of the important points of her investigation concerns the link between the Eurodif (European Gaseous Diffusion Uranium Enrichment Consortium) affair and a series of terrorist acts in France.
Eurodif, which means European Gaseous Diffusion Uranium Enrichment Consortium, is a subsidiary of the French company AREVA, which operates a uranium enrichment plant established at the Tricastin Nuclear Power Center in Pierrelatte in Drôme.
K-25 was the prototype for later Oak Ridge gaseous diffusion facilities and those at Paducah, Kentucky and Portsmouth, Ohio.
USEC ceased enrichment operations at the Portsmouth Gaseous Diffusion Plant in May 2001 after it consolidated operations at the Paducah Gaseous Diffusion Plant in Kentucky.
The Portsmouth plant, so named because of its proximity to the city of Portsmouth, Ohio, was one of three gaseous diffusion plants in the United States, alongside the K-25 plant in Oak Ridge, Tennessee and the Paducah Gaseous Diffusion Plant in Kentucky.