Multiplicative inverse | inverse-square law | Quantum inverse scattering method | multiplicative inverse | inverse | Beta2-adrenergic agonist | Alpha-adrenergic agonist | The Agonist | '''Magnetization''' of a paramagnet as a function of Multiplicative inverse | Inverse synthetic aperture radar | Inverse problem | inverse problem | Inverse multiplexer | Direct–inverse language | direct–inverse language |
In biochemistry and pharmacology, an allosteric modulator is a substance which indirectly influences (modulates) the effects of an agonist or inverse agonist at a target protein, for example a receptor.
Ro4938581 is a nootropic drug invented in 2009 by a team working for Hoffmann-La Roche, which acts as a subtype-selective inverse agonist at the benzodiazepine binding site on the receptor.
It binds to the partial agonist effect at α2 likely to be responsible for the lack of anxiety produced by this drug when compared to older α5-preferring inverse agonists such as L-655,708.