The refuge is administered from offices in King Salmon, Alaska and was established to conserve Alaskan brown bears, caribou, moose, marine mammals, shorebirds, other migratory birds and fish, and to comply with treaty obligations.
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Fish species inhabiting the river and its related lakes and streams include sheefish, burbot, whitefish, sucker, king and chum salmon, northern pike and arctic grayling.
Oncorhynchus tshawytscha (Walbaum, 1792) – Chinook salmon, blackmouth, black salmon, chub salmon, Columbia River salmon, hookbill salmon, king salmon, Quinnat salmon, spring salmon, Tyee salmon, winter salmon