The Quesnel River supports a number of fish species, the most significant of which are Sockeye salmon (Oncorhynchus nerka), Rainbow trout (Oncorhynchus mykiss), Largescale sucker (Catostomus macrocheilus), Longnose sucker (Catostomus catostomus), Redside shiner (Richardsonius balteatus), Northern pikeminnow (Ptychocheilus oregonensis), Peamouth chub (Mylocheilus caurinus), and Lake chub (Couesius plumbeus).
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A 2002 study conducted the U.S. Fish and Wildlife Service documented the occurrence of seven species of fish in the immediate vicinity of the island, with round whitefish, trout-perch, and lake chub predominating.
The Borax Lake chub Gila boraxobius is a rare cyprinid fish found only in outflows and pools around Borax Lake, a small lake of the Alvord basin, Harney County, Oregon.