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on the association between the 5-HTTLPR polymorphism in the serotonin transporter gene and the personality trait neuroticism has been highly cited and was one of the first papers in personality genetics.
Other studies have associated neuroticism with genetic variations, e.g., with 5-HTTLPR — a polymorphism in the serotonin transporter gene.
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Another study has found that healthy subjects with a high neuroticism score tend to have higher DASB binding in the thalamus; DASB is a ligand that binds to the serotonin transporter protein.
Gene variants that have been investigated are, e.g., 5-HTTLPR in the serotonin transporter gene and gene variants in XBP1.