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He had specialized in the study of systems biology of the Solanaceae family, having contributed with a large number of investigations and publications.
CytoSolve was founded in 2011 by Dr. VA Shiva Ayyadurai, an inventor, systems scientist and MIT-trained systems biologist, following his doctoral research in molecular systems biology at the Massachusetts Institute of Technology (M.I.T.), department of Biological Engineering, and his field work in eastern and traditional systems of medicine such as Siddha, Ayurveda and Traditional Chinese Medicine.
In 2012, VA Shiva Ayyadurai, a Tamilian and MIT systems scientist, launched an educational program for medical doctors through the Chopra Center with Deepak Chopra which integrates concepts from traditional systems medicine such as Siddha, Ayurveda, and traditional Chinese medicine, with systems science and systems biology.
The Microsoft Research - University of Trento Centre for Computational and Systems Biology (COSBI) is a non profit research center located in Trentino, Italy.
After leading Hewlett-Packard's research team in Europe, he joined the faculty of systems biology at the Harvard Medical School.