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Appin was for decades a major wheat-growing, and dairy-farming area, but wheat rust, and new railways reaching other primary producing areas of the State, reduced its importance.
The late author Sheldon H. Harris in his book Factories of Death: Japanese Biological Warfare, 1932-1945, and the American cover up wrote that field tests for wheat rust and rice blast were conducted throughout 1961 in Okinawa and at "at several sites in the midwest and south", although these were probably part of Project 112.
He inoculated sporidia from the winter spores of the wheat rust on the leaves of the "common barberry" (Berberis vulgaris).