The plot revolves around a girl called Mikiko "Kuromi" Oguro who grows up watching the fictional anime Luis Monde III.
The island's super-intelligent defense mechanism, however, proves to be too much for Lupin, Jigen, and Goemon to handle by themselves.
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Meanwhile Fujiko, pretending to be a secretary, is ordered to protect the general's daughter who turn out to be the daughter of a scientist that is held prisoner by Headhunter.
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Lupin has set his sights on the national treasure of the country of Zufu, placed for safe-keeping on a mysterious floating island by the country's late king.
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When Inspector Zenagata shows up and put the handcuffs on Lupin but he escape with a fake hand.
Lupin, Jigen, and Goemon are at their Manhattan hideout plotting their next caper, when suddenly a large masked man bursts in.
He stars as the title character in his own manga as a thief (à la Lupin III), and even star as the English cyborg private detective Sherlock Homespun (sometimes written Sherlock Holmespan) in the 1980 Astro Boy Anime and in the Game Boy Advance game Astro Boy: Omega Factor.
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He also cited as inspiration specific Japanese cartoonists who he felt had successfully portrayed sex in animation such as Monkey Punch, the creator of Lupin III.
During his tenure as a Drug G-man, Ōtsuka would see the release of two types of firearms that later would show up in his animations: the Beretta M1951 and the Colt Government – both appearing in the Lupin III series (the former used by Fujiko Mine and the latter by Inspector Zenigata).
Goemon Ishikawa XIII, his fictional descendant, created by Monkey Punch for his manga series Lupin III.
Monkey Punch (born 1937), manga artist and creator of Lupin III