Yemassee is accessible from three exits along Interstate 95 (exits 33, 38 and 42), which runs to the west of the town limits.
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The town takes its name from the Native American tribe of the same name, the Yamasee, which was the most important Indian ally of South Carolina until the Yamasee War of 1715.
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William Gilmore Simms published a novel, The Yemassee: A Romance of Carolina, in the nineteenth century, and the University of South Carolina in Columbia publishes a literary journal named Yemassee.