The title Duke of the Infantado (Spanish Duque del Infantado) was granted to Diego Hurtado de Mendoza y Figueroa, son of Íñigo López de Mendoza, 1st Marquis of Santillana, by the Catholic Monarchs, Ferdinand II of Aragon and Isabella I of Castile, on 22 July 1475.
As a politician, Don Íñigo remained loyal to Juan II throughout his life, for which he was richly rewarded with land and the title of Marquis of Santillana in 1445, after the First Battle of Olmedo.
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His sixth son from the marriage would one day become Cardenal Mendoza.
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He probably went to Italy in 1529 with Charles V, in the company of the fourth Duke of the Infantado, Íñigo López de Mendoza, marqués de Santillana.
He was the eldest son of the well known literary man of the 15th century, Íñigo López de Mendoza y Lasso de la Vega, (1398–1458), 1st marquis of Santillana since 1447.
He inherited the literary taste of his uncle Iñigo López de Mendoza y de la Vega, Marquis of Santillana, and was greatly esteemed in his own age; but his reputation was afterwards eclipsed by that of his nephew Jorge Manrique (died 1478), the son of his eldest brother Rodrigo Manrique de Lara, (died 1476), and whose Coplas por la muerte de su padre were continually reproduced.
One of the young children besides the senior, a sixth child, of famous literary man Iñigo López de Mendoza, (1398–1458), was the Bishop of Calahorra and of Siguenza since 1473 and later Cardinal of Toledo, the highest ecclesiastical distinction in Spain from a Pope, became to be known as Pedro González de Mendoza, (1428–1495), a.k.a. Cardinal and statesman Cardenal Mendoza.
The cardinal's and the 1st duke of Infantado father, Íñigo López de Mendoza, 1st marquis of Santillana-- to use the title he was awarded in the last years of his life --, was a poet, and was conspicuous during the troubled reign of John II of Castile, deceased 1453.
Among his direct descendants are major Spanish poets and writers Inigo Lopez de Mendoza, Jorge Manrique and Diego Hurtado de Mendoza.