The title Duke of the Infantado (Spanish Duque del Infantado) was granted to Diego Hurtado de Mendoza y Figueroa, son of Íñigo López de Mendoza, 1st Marquis of Santillana, by the Catholic Monarchs, Ferdinand II of Aragon and Isabella I of Castile, on 22 July 1475.
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He probably went to Italy in 1529 with Charles V, in the company of the fourth Duke of the Infantado, Íñigo López de Mendoza, marqués de Santillana.