The APHIS airport inspection program was begun in 1984 at Los Angeles International Airport.
In June 2009, the United States Department of Agriculture (USDA) Animal and Plant Health Inspection Service (APHIS) approved the first canine influenza vaccine.
Under the new law, the Animal and Plant Health Inspection Service (APHIS) retains broad authority to inspect, seize, quarantine, treat, destroy or dispose of imported plant and animal materials that are potentially harmful to U.S. agriculture, horticulture, forestry, and, to a certain degree, natural resources.
Appearance of the disease in the United States in early 1996 resulted in the Animal and Plant Health Inspection Service (APHIS) implementing an emergency quarantine, inspection, and certification program for wheat moving out of the infested areas, along with regulations on sanitizing machinery and storage facilities.
In the US, laboratory mice are not regulated under the Animal Welfare Act administered by the USDA APHIS.
The Plant Quarantine Act, originally enacted in 1912 (7 U.S.C. 151 et seq.), gave the Animal and Plant Health Inspection Service (APHIS) authority to regulate the importation and interstate movement of nursery stock and other plants that may carry pests and diseases that are harmful to agriculture.
The act and its applicable guidelines are managed by the Animal and Plant Health Inspection Service (APHIS) of the United States Department of Agriculture (USDA).