While no synthases specific to Artemisia absinthium have been sufficiently isolated to recreate this particular sesquiterpene formation in vitro, the general reaction scheme presented here portrays a likely scenario for Absinthin biosynthesis through the use of terpene intermediates utilized in the biosynthesis of Germacrene A, another sesquiterpene lactone.
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The full biosynthesis of Absinthin in Artemisia absinthium has not been elucidated, but a great portion of it can be inferred from the natural product precursors required to access Absinthin.
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Absinthin is a naturally produced sesquiterpene lactone from the plant Artemisia absinthium (Wormwood).