Like cowden syndrome, patients with Lhermitte–Duclos disease often have mutations in enzymes involved in the Akt/PKB signaling pathway, which plays a role in cell growth.
Akt/PKB signaling pathway | AKT | Akt |
"The IRS2-Akt pathway in midbrain dopaminergic neurons regulates behavioral and cellular responses to opiates."
Central Archives of Historical Records (Polish: Archiwum Główne Akt Dawnych) in Warsaw is one of the four national archives of Poland.
This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor 6 (TRAF6), which indicated this protein may have a role in the regulation of cell apoptosis.
Simultaneously, tumor cells need to upregulate oncogenes, which promote or cause downstream activation of growth factors and cell survival signals such as Ras, Mitogen-activated protein kinase kinase, VEGF, or Akt.
Erik Frey in the 1955 West German film Der Letzte Akt (Hitler: The Last Ten Days).