Flavocoxid has been associated with liver toxicity in prospective clinical trials published in the Annals of Internal Medicine.
In September 2004, editors of several prominent medical journals (including the New England Journal of Medicine, The Lancet, Annals of Internal Medicine, and JAMA) announced that they would no longer publish results of drug research sponsored by pharmaceutical companies unless that research was registered in a public database from the start.
Accordingly, Suzanne and Robert Fletcher (editors of Annals of Internal Medicine at the time) spearheaded the preparation of an application to hold a conference at the Rockefeller Foundation Conference and Study Center in Bellagio, Italy, to consider the needs of medical journal editors globally and to devise a plan to meet those needs.
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