July 29, 1959 (Ansei 5): Tairo Ii Naosuke signs Japanese-American Treaty of Amity and Commerce (also known as the "Harris Treaty"), which was a follow-up to the 1854 Treaty of Kanagawa.
1862 (Bunkyū 2): The Bunkyū Reforms relax restrictions on daimyo which had been imposed by former Tairo Ii Naosuke in the Ansei era.
Soon afterwards, it became the residence for a delegation of Russians under Vice-Admiral Euphimy Vasil'evich Putiatin, who was trapped in Shimoda at the end of 1854 when a tsunami caused by the Ansei-Tōkai earthquake destroyed his fleet.