The Jewish surnames Antokoletz, Antokolsky and variants derive from the Polish form of the name of the city, Antokol.
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One of the greatest Lithuanian Baroque masterpieces, the Roman Catholic Church of St. Peter and St. Paul, is situated in Antakalnis, as is Sapieha Palace (Sapiegų rūmai).
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The Botanical Garden of Vilnius University lies in Kairėnai, the settlement in the eastern part of the district.
It was formed in the present-day Antakalnis Secondary School in Vilnius by Andrius Mamontovas, Arnoldas Lukošius and Darius Tarasevičius in 1983 under the name of Sunki Muzika (with a literal meaning of "heavy music"), few months later Algis Kriščiūnas joined the band.