McMackin directed at over seventy-three films between 1912 and 1916 directing films such as When Empty Hearts Are Filled and the The Altar of Ambition in 1915 working with actors such as Harry von Meter, Louise Lester, Vivian Rich and David Lythgoe.
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Francis X. Bushman and Beverly Bayne appeared as the stars in the Essanay films being filmed in Ithaca.
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