When the Ottoman general Özdemir Pasha, who had been made governor of the Ottoman province of Habesh, crossed over from Jeddah in 1557 and occupied Massawa, Arqiqo and finally Debarwa, capital of the Bahri negassi, Yeshaq led the local peasantry against the invaders, recapturing Debarwa and seizing the "immense treasure" the invaders piled up within.
When the Ottomans attempted to advance inland to capture Debarwa in 1588, Emperor Sarsa Dengel responded by sacking Arqiqo the following year.