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unusual facts about Autoimmune



Ageing

A number of diseases associated with ageing, such as atrophic gastritis and Hashimoto's thyroiditis, are probably autoimmune in this way.

ANCA

Anti-neutrophil cytoplasmic antibody, proteins detected in a number of autoimmune disorders

Annabel Jarman

She has Crohn's disease, an autoimmune disorder of the gastrointestinal system, and received a scholarship recognizing her fight against the disease.

APLA

Anti-phospholipid antibody syndrome, an autoimmune condition that may be seen in systemic lupus erythematosus

Autoimmune inner ear disease

Autoimmune inner ear disease was first described by Dr. Brian McCabe of the University of Iowa in 1979.

Autoimmunity

Recently, PTPN22 has been associated with multiple autoimmune diseases including Type I diabetes, rheumatoid arthritis, systemic lupus erythematosus, Hashimoto’s thyroiditis, Graves’ disease, Addison’s disease, Myasthenia Gravis, vitiligo, systemic sclerosis juvenile idiopathic arthritis, and psoriatic arthritis.

Brett Deacon

On 19 December 2013, Deacon was forced to retire due to a diagnosis of lupus, an autoimmune disease which in his case led to potentially life-threatening blood clots; he was immediately placed on blood thinners.

Causes and origins of Tourette syndrome

Autoimmune processes may affect tic severity in some cases: the unproven and contentious hypothesis that Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal infections, PANDAS, plays a role in the onset of tic disorders and OCD is a current focus of research.

Doniach

Deborah Doniach (1912–2004), clinical immunologist and pioneer in the field of autoimmune diseases

Hemolysis

In vivo hemolysis can be caused by a large number of medical conditions, including many Gram-positive bacteria (e.g., Streptococcus, Enterococcus, and Staphylococcus), some parasites (e.g., Plasmodium), some autoimmune disorders (e.g., drug-induced hemolytic anemia), some genetic disorders (e.g., Sickle-cell disease or G6PD deficiency), or blood with too low a solute concentration (hypotonic to cells).

IDDM

Insulin-Dependent Diabetes Mellitus, now known as Diabetes mellitus type 1, an autoimmune disease resulting in the destruction of insulin-producing cells.

Immunoglobulin E

IgE is known to be elevated in various autoimmune disorders such as Lupus(SLE), Rheumatoid Arthritis(RA) & psoriasis, and is theorized to be of pathogenetic importance in RA and SLE by eliciting a hypersensitivity reaction.

Judith Rich Harris

Since 1977, Harris has suffered from a chronic autoimmune disorder, diagnosed as a combination of lupus and systemic sclerosis.

Nucleoporin 62

Antibodies to p62 complex are involved in 1 or more autoimmune diseases.

Onygenales

The Onygenales are important as emerging human pathogens because of the rising rates of immunosuppression due to live-organ transplant, HIV/AIDS, and autoimmune disorders such as Lupus erythematosus.

PANDAS

To establish that a disorder is an autoimmune disorder, Witebsky criteria requires that there be (1) a self-reactive antibody, (2) that a particular target for the antibody is identified (autoantigen) (3) that the disorder can be caused in animals and (4) that transferring antibodies from one animal to another triggers the disorder (passive transfer).

Paul Janssen

2008: Professor Marc Feldmann, FMedSci, FAA, FRS and Emeritus Professor Sir Ravinder Maini, FRCP, FMedSci, FRS of The Kennedy Institute of Rheumatology, Imperial College London, received the 2008 Dr. Paul Janssen Award for their role in the discovery of tumor necrosis factor-alpha, or TNF-alpha, as an effective therapeutic target for rheumatoid arthritis and other autoimmune diseases.

Protective autoimmunity

The term ‘protective autoimmunity’ was coined by Prof. Michal Schwartz of the Weizmann Institute of Science (Israel), whose pioneering studies were the first to demonstrate that autoimmune T lymphocytes can have a beneficial role in repair, following an injury to the central nervous system (CNS).

Sicca

Sicca syndrome - Sicca means "dryness", and may refer to Sjögren's syndrome, or to oral dryness (xerostomia) and eye dryness ("keratoconjunctivitis sicca") which is not caused by autoimmune diseasees such as Sjögren's.

Tabalumab

Tabalumab (LY 2127399) is an anti-B-cell activating factor (BAFF) human monoclonal antibody designed for the treatment of autoimmune diseases and B cell malignancies.

Transition state theory

Purine nucleoside phosphorylase (PNP) is an enzyme involved in the catabolism and recycling of nucleosides and is a target for the development of novel therapeutic agents for T-cell apoptosis in leukemia and in autoimmune diseases.


see also