The artery is essential to the imaginary axis of Barrio Norte in Buenos Aires, comprising the areas influenced by the route of the avenue through Retiro, Recoleta and Palermo neighborhoods, it is considered one of the main shopping and strolling areas of the city, its many boutiques range from elegant to edgy, which has led it to be dubbed the 'Avenue of Fashion'.
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It continues westward along the Retiro area, passing by the Brunetta ("Olivetti") Building (built in 1964, one the first in Buenos Aires designed in the International Style) and through the massive Avenida 9 de Julio, which was opened through the Retiro area in the early 1970s.
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The declaration of autonomy from the Spanish Empire in 1810 led city officials to rename it Calle Estrecha (the "Narrow Street").
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The Greek Revivalist Argentine Scientific Society and the Art Deco Regina Theatre follow and, past Avenida Callao, Santa Fe Avenue enters its Recoleta stretch.
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