Many of Mexico City's emblematic colonias (such as Condesa, Roma, Del Valle, Napoles, San Ángel, Pedregal) are either crossed or on the side of Insurgentes.
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The northern terminus is located in the intersection with Avenida Acueducto where it becomes the highway to Pachuca.
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An express bus service, the "Metrobús", based on the successful Curitiba model, was built down Avenida Insurgentes, cutting through the city some 20 km from north to south.