Its mechanism of action remains poorly defined however, with GABAergic, NGF and BDNF release promoting, MT1 receptor antagonism, MT3 receptor antagonism, and sigma agonism suggested as potential mechanisms.
His postdoctoral training was with Michael E. Greenberg at Harvard Medical School where he worked on regulation of differentiation by extracellular signals and calcium regulation of BDNF expression.
"Essential role of BDNF in the mesolimbic dopamine pathway in social defeat stress."