In 1976 the U.S. Congress formed the Commission for the Control of Huntington’s Disease, and as part of their work, Wexler and the team travelled to Barranquitas and Lagunetas, two settlements on Lake Maracaibo, Venezuela, where villagers had a particularly high occurrence of Huntington's.
As a private architect he produced the designs for the residences of Secundino Lozana (El Cortijo) in Barranquitas and Dionisio Trigo in Santurce, the General Electric store in San Juan, Colegio San José in Río Piedras and the Casino de Puerto Rico in El Condado.