After qualifying as a doctor, Bresnihan specialised in rheumatology at Guy's Hospital in London before working with Morris Ziff at the University of Texas Southwestern Medical School before returning to Ireland to set up a laboratory at the UCD Medical School and St. Vincent's University Hospital.
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In 1991 UCD created a chair of Rheumatology for Bresnihan and in 2009 he was honoured as a "Master" by the American College of Rheumatology.
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