Battle of Issus, in 333 BC, in which Alexander the Great defeated Darius III
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King Darius III of Persia executes Charidemus, a Greek mercenary leader living in exile in Persia, for criticising preparations taken for the Battle of Issus.
It's not clear whether this 'great battle' refers to the battle of Issus or of Gaugamela, or both.
The fourth and fifth battles are respectively the Battle of Issus and the Battle of Gaugamela against King Darius III of Persia.
Among other works he commissioned an important suite of paintings from various artists, including the Battle of Issus by Albrecht Altdorfer.