She is the sister of Pakistani film and television actors Javed Sheikh and Saleem Sheikh.
Azra Sherwani worked with actors of all generations — from Qazi Wajid, Subhani Ba Yunus, Imtiaz Ahmed, Begum Khurshid Mirza, Qurban Jilani, Shakeel, Shafi Mohammad, Talat Iqbal, Anwar Maqsood, Akbar Subhan, Behroze Sabzwari, Shahnaz Sheikh, Marina Khan, Ishrat Hashmi, Jamshed Ansari, Babar Ali, Mazhar Ali, Mishi Khan, Atiqa Odho, Sania Saeed, Sajid Hasan and Sadia Imam.