His father was the rich merchant Paolo Spada (unrelated to the Spada family of ancient nobility) who had directed him early on to a career in the church, though the generations before his had been colliers.
One of his best known paintings is a depiction of the Revolt of Masaniello in the Piazza del Mercato in Naples, with figures by Cerquozzi, painted for Cardinal Bernardino Spada in 1648 and now in the Galleria Spada in Rome.
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The collection was originally assembled by Cardinal Bernardino Spada in the 17th century, by his brother Virgilio Spada and added to by his grandnephew Cardinal Fabrizio Spada,
(Portrait of Roman Catholic Cardinal Bernardino Spada by Guido Reni, c. 1631.)