In a well known case of biopiracy, bioprospectors from South Africa’s Council for Scientific and Industrial Research (CSIR) realized that the plant was marketable and patented its use as an appetite suppressant without recognizing the Sans' traditional claims to the knowledge of the plant and its uses.
The Maya ICBG bioprospecting controversy took place in 1999–2000, when the International Cooperative Biodiversity Group led by Ethnobiologist Dr. Brent Berlin was accused of being engaged in unethical forms of bioprospecting (biopiracy), by several NGOs and indigenous organizations.
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Hoodia (A famous case of ethical complications of bioprospecting in South Africa)