Brian Eno | Brian Mulroney | Brian May | Brian Wilson | Brian Ferneyhough | Harold Bloom | Orlando Bloom | Hugh O'Brian | Claire Bloom | Brian Williams | Brian Stableford | Brian Aldiss | Brian | What About Brian | Brian Clough | Brian Stokes Mitchell | Brian Lara | Brian De Palma | Brian Dennehy | Brian Michael Bendis | Brian Lenihan | Brian Cox | Brian Boru | Patrick O'Brian | Brian Setzer | Brian McKnight | Brian Evenson | Brian Culbertson | Brian Cox (actor) | Brian Aherne |
Musician Mike Patton reprises his role as the voice of the Darkness while Brian Bloom voices Jackie Estacado, replacing Kirk Acevedo who provided the voice of Jackie in the previous game.