The refuge and its surrounding waters are home to at least two plants and eight animals on the Federal endangered species list including; the Antillean Manatee (Trichechus manatus manatus), the Brown Pelican (Pelecanus occidentalis), and four species of sea turtles.
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As well as being the last refuge of the Antiguan Racer, it is also home to a variety of other endangered creatures including the rare lizard Ameiva griswoldi, Brown Pelicans (Pelecanus occidentalis), West Indian Whistling Ducks and Red-billed Tropicbirds (Phaethon aethereus).