RAF Burtonwood was mainly used by the United States Air Force between 1942 and closure of the main airfield in 1958 and was the biggest US airbase in Europe.
In the 1920s the brewery was bought by the Burtonwood Brewery Company, who made further alterations before it was demolished in 1940 and a new brewery house was built.
His important commands included Commander, U.S. Army Troop Support Command in St. Louis, Missouri; Commander, Defense Industrial Support Center in Philadelphia, Pennsylvania; Commander, Defense Reutilization and Marketing Service in Battle Creek, Michigan; Commander, 88th Supply and Service Battalion in Vietnam; Commander, Regional Support Activity, Military Region II, Vietnam; Commander, U.S. Army Logistic Evaluation Agency at New Cumberland Army Depot; and Commander, Burtonwood Army Depot in England.
In the late 1950s, it was suggested that Burtonwood would be a better site for a regional airport than either of the sites now occupied by Liverpool John Lennon Airport or Manchester Airport.
In 1948 the Americans occupied RAF stations including Fairford, Brize Norton, Burtonwood, Greenham Common, Mildenhall, Lakenheath and Woodbridge to build up a deterrent in Europe against the Soviets.