The normal ligands for this receptor, RANTES, MIP-1β, and MIP-1α, are able to suppress HIV-1 infection in vitro.
His most recent work, first published in the 2005 issue of Science, involves the ethnic group-specific role of CCR5 haplotype and CCL3L1 gene copy number on the progression of HIV to AIDS.
CCR5 |
Researchers at Ono have discovered a novel series of potent CCR5 small molecule antagonists.
A low percentage of long-term nonprogressors have been shown to have inherited mutations of the CCR5 receptor of T cell lymphocytes.